Therapy Pipeline

SELECTED LITERATURE

Below please find a list of selected publications describing the PiCSO® concept and technology.

  1. EuroIntervention. 2015 May 19;11(1):37-44
    Pressure-controlled intermittent coronary sinus occlusion (PICSO) in acute ST-segment elevation myocardial infarction: results of the Prepare RAMSES safety and feasibility study
    van de Hoef TP, Nijveldt R, van der Ent M, Neunteufl T, Meuwissen M, Khattab A, Berger R, Kuijt WJ, Wykrzykowska J, Tijssen JG, van Rossum AC,Stone GW, Piek JJ.
    Link
  2. EuroIntervention. 2015 May 19;11(1):19-23
    Transcoronary sinus catheter interventions: back in the repertoire? 
    Mohl W, Milasinovic D, Maurer G.
    Link
  3. Cardiovasc Revasc Med. 2015 Jan;16 (1): 36–46
    PICSO: from myocardial salvage to tissue regeneration
    Mohl W, Gangl C, Jusić A, Aschacher T, De Jonge M, Rattay F.
    Link
    Audioslides
  4. EuroPCR 2014, Oral Presentation
    Pressure-controlled intermittent coronary sinus occlusion in acute STEMI: promising preliminary results of the Prepare-RAMSES trial
    van de Hoef T., Nijveldt R., van der Ent M., Neunteufl T., Meuwissen M., Khattab A., Wykrzykowska J., Tijssen J., van Rossum A., Piek J.
    Link
  5. EuroIntervention. 2013 Jul;9(3):398-406.
    Effect of pressure-controlled intermittent coronary sinus occlusion (PICSO) on myocardial ischaemia and reperfusion in a closed-chest porcine model.
    Khattab AA, Stieger S, Kamat PJ, Vandenberghe S, Bongoni A, Stone GW, Seiler C, Meier B, Hess OM, Rieben R.
    Link
  6. J Interv Cardiol. 2012 Dec;25(6):549-56.
    Intracoronary hemodynamic effects of pressure-controlled intermittent coronary sinus occlusion (PICSO): results from the First-In-Man Prepare PICSO Study.
    Van de Hoef TP, Nolte F, Delewi R, Henriques JP, Spaan JA, Tijssen JG, Siebes M, Wykrzykowska JJ, Stone GW, Piek JJ.
    Link
  7. Circ J. 2008 Apr;72(4):526-33.
    Myocardial protection via the coronary sinus.
    Mohl W, Komamura K, Kasahara H, Heinze G, Glogar D, Hirayama A, Kodama K.
    Link
  8. J Thorac Cardiovasc Surg. 2007 Jun;133(6):1581-7.
    Beck and Back A Paradigm Change in Coronary Sinus Interventions
    Weigel G, Kajgana I, Bergmeister H, Riedl G, Glogar HD, Gyöngyösi M, Blasnig S, Heinze G, Mohl W.
    Link
  9. Wien Klin Wochenschr. 2007;119(11-12 Suppl 1):31-2.
    Influences of signal quality for determination of PICSO timing.
    Mina S, Meindl M, Mohl W.
    Link
  10. Wien Klin Wochenschr. 2007;119(11-12 Suppl 1):30.
    Soluble plasma factors derived from ischemic, PICSO-treated, porcine hearts are not responsible for HO-1 and VEGF mRNA expression in endothelial cells.
    Schuler M, Winter B, Eichmair E, Nigisch A, Mohl W, Weigel G.
    Link
  11. Wien Klin Wochenschr. 2007;119(11-12 Suppl 1):29.
    PICSO in progress: lactate, oxygen, eNOS, iNOS, MMP and TIMP in the PICSO treated myocardium–a preview.
    Lechner J, Grünbichler H, Schrutka I, Waldthaler A, Franz C, Mohl W.
    Link
  12. Wien Klin Wochenschr. 2007;119(11-12 Suppl 1):23-6.
    Do long term effects after PICSO endorse the potential of cardiac regeneration after acute myocardial infarction?
    Kasahara H, Komamura K, Glogar D, Kodama K, Hirayama A, Mohl W.
    Link
  13. Interact Cardiovasc Thorac Surg. 2005 Feb;4(1):66-9.
    Intermittent pressure elevation of the coronary venous system as a method to protect ischemic myocardium.
    Mohl W, Kajgana I, Bergmeister H, Rattay F.
    Link
  14. J Thorac Cardiovasc Surg. 2004
    The salvage potential of coronary sinus interventions
    Syeda B, Schukro C, Heinze G, Modaressi K, Glogar D, Maurer G, Mohl W.
    Link
  15. Circulation. 1992 Nov;86(5 Suppl):II352-7.
    Reduction of infarct size with coronary venous retroperfusion.
    Lazar HL, Haan CK, Yang X, Rivers S, Bernard S, Shemin RJ.
    Link
  16. J Cardiovasc Surg (Torino). 1992 Sep-Oct;33(5):538-44.
    Retroperfusion and balloon support to improve coronary revascularization.
    Lazar HL, Yang XM, Rivers S, Treanor P, Bernard S, Shemin RJ.
    Link
  17. Am Heart J. 1991 Feb;121(2 Pt 1):442-9.
    Coronary sinus occlusion: effect on ischemic left ventricular dysfunction and reactive hyperemia.
    Jacobs AK, Faxon DP, Coats WD, Vogel WM, Ryan TJ.
    Link
  18. J Biomed Eng. 1989 Nov;11(6):482-6.
    Computation of diagnostic data from coronary sinus pressure: a comparison between two possible models.
    Schreiner W, Neumann F, Schuster J, Froehlich KC, Sun Y, Mohl W.
    Link
  19. Biomed Instrum Technol. 1989 Mar-Apr;23(2):136-43.
    A closed-loop system for pressure-controlled intermittent coronary sinus occlusion.
    Sun Y.
    Link
  20. Ann Thorac Surg. 1988 Aug;46(2):202-7.
    Improved distribution of cardioplegia with pressure-controlled intermittent coronary sinus occlusion.
    Lazar HL, Khoury T, Rivers S.
    Link
  21. Ann Thorac Surg. 1988 Aug;46(2):192-201.
    Clinical evaluation of pressure-controlled intermittent coronary sinus occlusion: randomized trial during coronary artery surgery.
    Mohl W, Simon P, Neumann F, Schreiner W, Punzengruber C.
    Link
  22. Circulation. 1988 Jun;77(6):1403-13.
    Effect of pressure-controlled intermittent coronary sinus occlusion on pacing-induced myocardial ischemia in domestic swine.
    Fedele FA, Capone RJ, Most AS, Gewirtz H.
    Link
  23. Cardiovasc Res. 1988 Apr;22(4):265-76.
    Computation of derived diagnostic quantities during intermittent coronary sinus occlusion in dogs.
    Schreiner W, Neumann F, Schuster J, Froehlich KC, Mohl W.
    Link
  24. J Card Surg. 1987 Dec;2(4):467-93.
    Coronary sinus interventions: from concept to clinics.
    Mohl W.
    Link